Drug Metabolite
Drug metabolite results when a drug is metabolized into a modified form which continues to produce effects. Drug metabolism redox reactions such as heteroatom dealkylations, hydroxylations, heteroatom oxygenations, reductions, and dehydrogenations can yield active metabolites, and in rare cases even conjugation reactions can yield an active metabolite.
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Drug Metabolite 관련 제품 (2022)
관련 제품 (2022)
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Antibodies (1)
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Related Compound Screening Libraries (1)
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α-Demethylnaproxen (Standard)
0 Imagesα-Demethylnaproxen (Standard) is the analytical standard of α-Demethylnaproxen (HY-W086896). This product is intended for research and analytical applications. α-Demethylnaproxen (Compound 6-MNA) is the major metabolite of Nabumetone (HY-B0559). Nabumetone is an orally active non-acidic anti-inflammatory agent, acts as a potent and selective COX-2 inhibitor.
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Monohydroxy Netupitant-d6
0 ImagesCat. No.: HY-G0012SCAS No.: 2070015-07-3Monohydroxy Netupitant-d6 is the deuterium labeled Monohydroxy Netupitant, which is a metabolite of Netupitant.
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3',4'-Dihydroxytrimethoprim
0 ImagesCat. No.: HY-W716241CAS No.: 71525-06-93',4'-Dihydroxytrimethoprim is a Trimethoprim (HY-B0510) derivative. 3',4'-Dihydroxytrimethoprim forms via sequential O-demethylation of Trimethoprim in human liver microsomes. 3',4'-Dihydroxytrimethoprim can be used for metabolic research.
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2-Amino-2'-fluoro-5-nitrobenzophenone
0 Images2-Amino-2'-fluoro-5-nitrobenzophenone is a precursor in the synthesis of benzodiazepines. 2-Amino-2'-fluoro-5-nitrobenzophenone is also an acid hydrolysis product of Flunitrazepam.
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N-Desmethyl clomipramine-d6
0 ImagesCat. No.: HY-12388S1Synonyms: Desmethylclomipramine-d6; Norclomipramine-d6N-Desmethyl clomipramine-d6 (Desmethylclomipramine-d6; Norclomipramine-d6) is the deuterated-labeled N-Desmethyl clomipramine (HY-12388). N-Desmethyl clomipramine (Desmethylclomipramine; Norclomipramine) is the orally active major active metabolite of the tricyclic antidepressant Clomipramine (HY-B0457A), possessing multiple activities including anti-inflammatory, antioxidant, antibacterial, and antiparasitic effects. N-Desmethyl clomipramine blocks autophagosome-lysosome fusion, leading to the accumulation of LC3-II, p62, ATG7, WIPI2, and ATG5-12, reactivates the p53/p21 pathway, induces apoptosis through C-PARP and C-CAS3, and inhibits the proliferation, migration, and invasion of renal cancer cells. N-Desmethyl clomipramine inhibits LdTOPIA, inducing R-loop accumulation in the nucleus of Leishmania, ultimately causing parasite death. N-Desmethyl clomipramine can be used for research on depression, metastatic renal cell carcinoma, and leishmaniasis.
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Pantoprazole sulfone
0 ImagesCat. No.: HY-117225CAS No.: 127780-16-9Pantoprazole sulfone is the major metabolite of Pantoprazole (HY-17507), which is a potent H+/K+-ATPase inhibitor.
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Tazarotenic acid-d8
0 ImagesCat. No.: HY-W742417Synonyms: AGN 190299-d8Tazarotenic acid-d8 (AGN 190299-d8) is the deuterium labeled Tazarotenic acid (HY-101108). Tazarotenic acid is the metabolite of Tazarotene (HY-15388).
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(S)-4-Hydroxymephenytoin
0 ImagesCat. No.: HY-W587570CAS No.: 82695-93-0(S) -4-Hydroxy mephenytoin is a metabolite derived from the stereoselective metabolism of mephenytoin. Mephenytoin, an anticonvulsant, is the CYP2C19 and CYP2B6 substrate.
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4-Oxofenretinide-d4
0 ImagesCat. No.: HY-109583SCAS No.: 2991099-34-2Synonyms: 4-Oxo-4-HPR-d44-Oxofenretinide-d4 (4-Oxo-4-HPR-d4) is deuterium labeled 4-Oxofenretinide. 4-Oxofenretinide (4-Oxo-4-HPR) is a metabolite of Fenretinide (HY-15373). 4-Oxofenretinide induces cell growth inhibition in ovarian, breast, and neuroblastoma tumor cell lines. 4-Oxofenretinide causes a marked accumulation of cells in G2-M. 4-Oxofenretinide induces cancer cell apoptosis through caspase-9.
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4'-Hydroxywarfarin
0 Images4′-Hydroxywarfarin is a regioisomeric phenolic derivative of Warfarin (HY-B0687). 4′-Hydroxywarfarin is a major metabolite of Warfarin in mammals and serves as a metabolic probe for the diversity of cytochrome P-450 isoenzymes.
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4-Methylamino antipyrine (Standard)
0 Images4-Methylamino antipyrine (Standard) is the analytical standard of 4-Methylamino antipyrine. This product is intended for research and analytical applications. 4-Methylamino antipyrine is an active metabolite of Metamizole. Metamizole is a pyrazolone non-steroidal anti-inflammatory drug (NSAID) and inhibits COX. Metamizole is an nonopioid analgesic agent and can be used for pain and fever. 4-Methylamino antipyrine has analgesic, antipyretic, and relatively weak antiinflammatory properties.
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Tiopronin disulfide
0 ImagesCat. No.: HY-W585823CAS No.: 21269-37-4
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Enoximone sulfoxide
0 ImagesCat. No.: HY-187722CAS No.: 83982-78-9Synonyms: MDL 19438
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DL-Sulforaphane N-acetyl-L-cysteine (Standard)
0 ImagesCat. No.: HY-132242RCAS No.: 334829-66-2Synonyms: SFN-NAC (Standard)Pipemidic acid (trihydrate) (Standard) is the analytical standard of Pipemidic acid (trihydrate). This product is intended for research and analytical applications. Pipemidic acid trihydrate, a derivative of Piromidic acid, is an antibacterial agent. Pipemidic acid trihydrate inhibits DNA gyrase. Pipemidic acid trihydrate is active against gram-negative bacteria including Pseudomonas aeruginosa as well as some gram-positive bacteria. Pipemidic acid trihydrate can be used for the research of intestinal, urinary, and biliary tract infections.
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Netupitant metabolite Monohydroxy Netupitant
0 ImagesCat. No.: HY-G0012CAS No.: 910808-12-7Synonyms: Monohydroxy NetupitantMonohydroxy Netupitant is the metabolite of Netupitant, which is a highly selective NK1 receptor antagonist.
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Labetalone hydrochloride (Standard)
0 ImagesLabetalone (hydrochloride) (Standard) is the analytical standard of Labetalone (hydrochloride). This product is intended for research and analytical applications. Labetalone hydrochloride is an impurity of Labetalol. Labetalol is an orally active adrenoceptor blocking agent which is a competitive antagonist at both alpha- and beta-adrenoceptor sites.
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AB-INACA
0 ImagesCat. No.: HY-150339CAS No.: 1887742-41-7AB-INACA is a metabolite of AB-CHMINACA.
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Aripiprazole N,N-Dioxide
0 ImagesCat. No.: HY-W741839CAS No.: 573691-13-1Aripiprazole N,N-dioxide is a metabolite of the atypical antipsychotic aripiprazole (HY-14546). It is formed from aripiprazole via oxidation.
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11-Dehydro thromboxane B3
0 ImagesCat. No.: HY-124353CAS No.: 129228-55-3Synonyms: 11-Dehydro-TXB311-Dehydro thromboxane B3 (11-Dehydro-TXB3) is a pro-inflammatory thromboxane lipid mediator that the body generates following administration of eicosapentaenoic acid. 11-Dehydro thromboxane B3 is an enzymatic metabolite of Thromboxane B3 (HY-113445) and also serves as a biomarker for Thromboxane A3 biosynthesis in humans in vivo. 11-Dehydro thromboxane B3 is used in metabolism-related research.
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Ethoxyquin dimer
0 ImagesEthoxyquin dimer is a dimer of Ethoxyquin (HY-B1425). Ethoxyquin dimer is an antioxidant. Ethoxyquin dimer can more readily accumulate in liver and adipose tissue compared with Ethoxyquin. Ethoxyquin above 10 mg/kg shows hepatotoxicity in mice.
